Installing C-PAC


System Requirements

C-PAC is designed to run in a *nix-like environment and thus does not support Windows. The C-PAC team actively tests C-PAC in Ubuntu Linux, although older versions of that distribution and other *nixes (such as Mac OS X) should work as well. As a general rule, C-PAC can operate on any machine capable of reliably running AFNI and FSL.

Hardware Requirements

  • A multiprocessor/multicore system (highly recommended)
  • 8 GB of RAM (for computationally-intensive processes such as anatomical registration using ANTS)
  • 5.7 GB of free hard disk space (8.3 GB with ANTs)

A Note About the *nix Command Line

This user guide assumes a basic level of experience using the command line. If you are new to the command line (also known as the terminal), the resources below will help you get started:

Installation Overview

If you are using Ubuntu (version 12/14) you can download and run with the following terminal commands as root:

chmod +x
sudo ./ -r

This will install all of the prerequisites and resources listed below. If you have previously installed versions of these, they will not be reinstalled, and the script will not check the release version to match the requirements of C-PAC.

Note: This script is intended for Ubuntu Linux 12/14, but it may work for older releases of Ubuntu.

For other operating systems, this page will guide you through the following C-PAC installation steps:

  • Installing the required system-level dependencies
  • Installing the required Python dependencies
  • Installing AFNI and FSL
  • Installing C3D and ANTS (optional, but recommended)
  • Installing the required C-PAC image resources
  • Installing C-PAC itself

It will also provide information on how to:

  • Test your installation.
  • Upgrade C-PAC to a new version.
  • Run C-PAC without installing.

Instructions for Installing Particular Dependencies

Installing System-Level Dependencies

A complete installation of C-PAC requires that the following dependencies be installed on your OS (and possibly other packages depending on your configuration):

  • cmake
  • make
  • build
  • git
  • unzip
  • libxp
  • netpbm
  • gcc (with Fortran and C++ compilers and libgfortran)
  • The Python developer libraries
  • lapack and its developer libraries
  • libcanberra (under Linux)
  • The Mesa OpenGL utility library
  • gsl
  • zlib and its developer libraries
  • Graphviz (optional; required for workflow graphs)
  • Xvfb
  • libxml
  • libxslt
  • Python developer libraries

The command to install all of these on Ubuntu 12/14 is:

sudo apt-get install -y cmake git make unzip libcanberra-gtk-module libxp6 netpbm libglu1-mesa gsl-bin zlib1g-dev graphviz graphviz-dev pkg-config build-essential libxml2-dev libxslt-dev python-dev xvfb

OS-Specific Instructions

Mac OS X:

  • Installing system-level and Python dependencies will be made much easier if you download the Xcode Command Line Tools from Apple (requires a free Apple account), which includes (among other things) Git and gcc.
  • You may want to consider using a package manager such as Homebrew, Macports, or Fink.

Ubuntu 16.04:

  • The apt-get command used for Ubuntu 12/14 works with libxp6 omitted. Unfortunately, libxp is no longer included in the Ubuntu repositories and will need to be compiled from source. The commands to accomplish this are as follows (note that these commands must be executed as the root user).
apt-get install autoconf autogen xutils-dev x11proto-print-dev
cd /tmp
git clone
cd libXp
make install

Installing Python Dependencies

Please ensure that you are using Python 2.7 and above, but not Python 3 (since it is not backwards-compatible). Though many computers come with Python pre-installed, C-PAC relies on a number of special-purpose packages, which are listed below. Packages with an asterisk can be installed through easy_install or pip. Installing Anaconda (64-bit version only), Miniconda or Enthought Canopy and using a package manager can simplify installation greatly. Instructions for Miniconda are given below.

Note: Specific maximum versions are required for the following dependencies. C-PAC is currently (temporarily) not compatible with versions past the following:

These specific versions can be installed via pip:

pip install networkx==1.11
pip install jinja2==2.7.2

The rest of the dependencies are as follows:


The following commands will install all the Python dependencies within a Miniconda environment:

chmod +x
./ -b
export PATH=~/miniconda/bin:${PATH}
echo 'export PATH=~/miniconda/bin:${PATH}' >> ~/.bashrc
conda create -y -n cpac python
source activate cpac
conda install -y cython numpy scipy matplotlib networkx==1.11 traits pyyaml jinja2==2.7.2 nose ipython pip wxpython pandas
pip install lockfile pygraphviz nibabel nipype patsy psutil boto3 INDI-Tools future==0.15.2 prov simplejson fs==0.5.4
source deactivate

OS-Specific Instructions

Mac OS X:

  • It is recommended that you use either Canopy or Anaconda/Miniconda to install Python packages such as wxPython, SciPy and NumPy. Manually installing these packages on OS X can be difficult and error-prone. If you use Anaconda/Conda, the commands above should install all packages seamlessly (assuming you download the Mac OS X Miniconda install script instead of the Linux script when using wget).

Installing AFNI and FSL

C-PAC harnesses the power of two leading neuroimaging software packages (AFNI and FSL) to perform key analyses. These packages must be installed before running C-PAC.

To install AFNI on a non-Fedora 21 64-bit Linux machine you may run the follow commands as the super user:

cd /tmp
tar xfz linux_openmp_64.tgz
mv linux_openmp_64 /opt/afni

For AFNI to be available globally on your machine, you should then add the following lines to the file located at /etc/bash.bashrc:

export PATH=/opt/afni:$PATH

If you open a new shell and type afni the AFNI console should now appear. If not, double-check the lines added to /etc/bash.bashrc for typos and make sure that /opt/afni contains the AFNI commands.

Note: Regarding the Neurodebian repository: We have encountered compatibility issues in the past with the Neurodebian binary for AFNI. For this reason, it is suggested that you follow the installation instructions above or the instructions from the AFNI homepage.

Note: On some Ubuntu systems, AFNI can have trouble locating the software library required for some of their tools (3dSkullStrip, and 3dHist). If you experience an error trying to run any of these tools, first attempt to re-install AFNI via the instructions on the AFNI homepage. If this does not resolve the issue, another solution involves locating your system’s GSL library and re-configuring:

   locate libgsl
-n /path/to/libgsl

For more details about installing AFNI (including instructions for other architectures) please refer to the AFNI manual here.

To install FSL on a Debian or Ubuntu-based Linux machine you may run the follow commands as the super user to install the Neurodebian repository, which contains a pre-packaged version of FSL that integrates seamlessly with the Debian ecosystem:

wget -O-$(lsb_release -cs).us-nh.full | tee /etc/apt/sources.list.d/neurodebian.sources.list
apt-key adv --recv-keys --keyserver 2649A5A9
apt-get update

Now install FSL using:

apt-get install -y fsl-5.0-complete

For FSL to be available globally on your machine, you should then add the following lines to the file located at /etc/bash.bashrc:

. ${FSLDIR}/etc/fslconf/

For more details about installing FSL (including instructions for other architectures) please refer to the FSL documentation here.

OS-Specific Instructions

Mac OS X:

  • In Mac OS X, you can make it so that a local user account can find AFNI by adding the lines in the instructions above to the .bashrc file in your home directory and then adding the following code to the .bash_profile file in your home directory.

    if [ -f ~/.bashrc ]; then
        source ~/.bashrc

Installing C-PAC Image Resources

During preprocessing and analysis, C-PAC utilizes many of the standard brain atlases and tissue maps provided by FSL. Additionally, C-PAC requires the following non-standard files in order to run properly:

  • Binarized tissue prior probability maps (used during tissue segmentation)
  • Symmetric versions of the MNI152 brain template and masks (used when calculating VMHC)

These files are included in the C-PAC Image Resources package, available here. You may install these files using the following commands or use the included script (

cd /tmp
tar xfz cpac_resources.tar.gz
cd cpac_image_resources
cp -n MNI_3mm/* $FSLDIR/data/standard
cp -n MNI_4mm/* $FSLDIR/data/standard
cp -n symmetric/* $FSLDIR/data/standard
cp -nr tissuepriors/2mm $FSLDIR/data/standard/tissuepriors
cp -nr tissuepriors/3mm $FSLDIR/data/standard/tissuepriors
cp -nr tissuepriors/4mm $FSLDIR/data/standard/tissuepriors
cp -n HarvardOxford-lateral-ventricles-thr25-2mm.nii.gz $FSLDIR/data/atlases/HarvardOxford

These commands perform the following steps:

  • The image resources are downloaded.
  • 3mm and 4mm MNI tempaltes are copied to the /data/standard directory of your FSL installation.
  • Files located in the /symmetric folder of the C-PAC Image Resources directory are copied to the /data/standard directory of your FSL installation.
  • The /2mm and /3mm folders located in C-PAC Image Resources directory are copied to /data/standard/tissuepriors directory of your FSL installation.

Installing C-PAC

Congratulations, you are now ready to install C-PAC itself!

C-PAC is available for download from the C-PAC Homepage. Click the button labeled “Download as tar.gz”. Unpack the downloaded archive and navigate to the new directory. To install C-PAC, run the command sudo python install. C-PAC will be installed alongside your other python packages. If this fails, check to make sure that you have all the dependencies installed. You may also install C-PAC using the commands below:

cd /tmp
git clone
cd C-PAC
python install

Testing Your C-PAC Installation

In a new terminal window, open iPython (or Python) and enter the command import CPAC. If installation was successful, this will execute without an error and present you with a blank new line. If you encounter an error (e.g. no module named C-PAC), try re-running the C-PAC install command above. If this does not work, see the Troubleshooting and Help Page. Note that if you do not open a new terminal window and are still within the C-PAC installation directory (‘C-PAC’), you may encounter errors that can be alleviated by leaving the ‘C-PAC’ directory.

Once you are able to successfully import CPAC it is safe to delete any setup files downloaded during the install process (e.g. Nipype and C-PAC downloads, FSL install scripts, etc.), as they are no longer needed.

Note: The test process described here only acts to confirm that the C-PAC python package has been correctly installed. To fully test C-PAC on your system, please see the Benchmark Page.

Updating C-PAC

C-PAC is being actively developed, and new versions (containing bug fixes and new features) are often released. To update to the latest version, simply download it from the C-PAC Homepage and repeat the instructions in the Installing C-PAC section above. A list of previous versions and the changes they contain is available on the Release Notes Page.

Note: If you are using Anaconda/Miniconda you may also use the following command (replacing ‘cpac’ with your environment name) to remove an old environment before creating a new environment to replace it.

conda remove --all -n cpac

Running C-PAC Without Installing

Users wishing to run C-PAC without installing it can do so by copying the downloaded C-PAC directory to the location of their choice. C-PAC can then be run by opening iPython (or Python) from within this directory. This is useful in cases where a user does not have sufficient privileges to install Python packages, but is running on a machine that already contains all C-PAC dependencies.

Some network centrality features will not be available without compiling the C-based elements. In order to do this without installing the rest of C-PAC, simply use the following command

python build_ext --inplace

Note: Unfortunately, it is not possible at this time to use the C-PAC GUI without installing C-PAC.